Growth hormone (Somatotropin)

Human growth hormone is a natural substance secreted by the pituitary gland. This is important for adequate and timely growth as well as human development from early childhood. Growth hormone (HGH) is secreted by the pituitary gland since birth and reached peak levels in late adolescence. It is known that in the 2nd decade of life, the level of HGH gradually decreases. More than 40 years somatotropic growth hormone is available for the treatment of diseases causing growth deficiency caused by chronic kidney failure, Turner syndrome.

HGH therapy is also using as a treatment of growth hormone deficiency associated with the presence of pituitary tumors. Another recent approved use of growth hormone has been the treatment of adults suffering from AIDS wasting syndrome.

However, over the past three decades, growth hormones have enjoyed unprecedented success on the market for other reasons. Elderly and middle-aged people seem to believe that HGH can slow down or stop aging. Athletes and young people want to improve their body condition and be more physically fit, improve performance.

Of all the stimulants abused by athletes, growth hormone is probably among the top three. Growth hormone in sports, such as drug abuse. Which is particularly characteristic of weightlifters or bodybuilders, where it is commonly used in combination with androgenic steroids.

History of somatotropin

In 1944, somatotropin was obtained from animal pituitary glands by scientists, and growth hormone was obtained in another way. Later in 1956, a human growth hormone was opened. A year later its clinical effectiveness was proved. The very first scandal related to the use of somatotropin happened to the Italian athlete – Sprinter Mennea, after which it began to catch in many others. Somatotropin is popular among different circles of society. People talking about it, they are interested in it, and opinions are also split.

After reaching the peak pulses of growth hormone (during growth spurt of a teenager), pulse amplitude gradually decreases with age. Although the frequency of release continues to remain, it increases during sleep and exercise.

Forms of somatotropin

It is hard to imagine that in the 80s was only the somatotropin extracted from pituitary glands of the deceased person. But after five years those who took this growth hormone was diagnosed with a rare disease – Creutzfeldt—Jakob disease, encephalitis which is a chronic and progressive form. The outcome of this disease was mental disorder and death, so the growth hormone derived from cadavers ceased to produce. The only exception is the Lithuanian company.

To date, the growth hormone drugs can be safely split on the methods of their obtaining such:

  • homologous – from the pituitary gland of the deceased person;
  • synthetic – has more than 1 amino acid than human growth hormone;
  • recombinant – the work of genetic engineers (the highest quality somatotropin).

Growth hormone in bodybuilding and metabolism

When you take somatotropin in bodybuilding, the HGH produced by the body stimulates a number of effects on your muscles. As your muscle mass increases, muscle tissue begins to work. Because your fat is burned, you will have more energy to work at an even higher level than before.

When you begin to climb new load levels, HGH will greatly aid in the muscle recovery. This hormone boosts immunity and healing, which means old injuries will be less disturbing . If you get new injuries, HGH will speed up your healing time.

Growth hormones affect lipid, protein and glucose metabolism. Growth hormone fibrinogenic doses boluses activate lipolysis and increase circulating unesterified fatty acids (NEFA).

This implies a shift from carbohydrate to lipid sources of energy and can lead to some reductions in total fat as well as an increase in body weight.

The effect on carbohydrate metabolism depends on the duration of exposure to growth hormone and circulating levels of NEFA. These include: increased production of glucose in the liver, violation of peripheral glucose uptake, inhibition of glycogen storage in the liver and skeletal muscles, increased peripheral insulin resistance and glucose tolerance.

Protein synthesis increases in skeletal muscles through enhanced intracellular signal transmission and transcription with reduced protein oxidation after exercise, indicating a pure anabolic effect on the metabolism of the whole organism.

From the above it is not difficult to conclude that the use of growth hormone:

  • will increase muscle mass and bone density
  • will reduce the amount of fat in the body
  • will increase physical activity
  • will increase cardiovascular tolerance to stress/exercise

Dosage and method of somatotropin application

What is growth hormone and why it is needed is already clear. Now, you need to understand how to take it. Growth hormone is never taken orally. It is always injected – subcutaneous or intramuscular. Growth hormone acts fairly quickly once it is absorbed by the bloodstream. Dosage of growth hormone is still not fully known. While recent studies show that it should be based on IGF levels, many doctors calculate it based on body weight. For adults, the dosage is about 0.01-0.1 mg per kg of body weight. This dosage depends on the type of product and what it should be used for.

Somatotropin is made in the form of a powder of a very light shade. Contains powder in a metered bottle, which comes with a solution for dilution. When you mix these two components, the prepared solution must be immediately injected so that it does not deteriorate. Somatotropin is best stored at low temperature, so it would be logical to store the package with the drug in the refrigerator.

Muscle growth hormone and its side effects

With the use of growth hormone in sports, there is a constant risk of overdose, as it may not be controlled by a professional. Overdose can lead to the development of destructive conditions caused by excessive production of growth hormone, such as acromegaly.

Since HGH stimulates cell growth, there is also a risk that it can activate the proliferation of unwanted cells such as cancer cells, causing the development of leukemia, prostate cancer and malignant tumors. Comparatively less serious side effects of growth hormone include fluid retention and joint pain.

Growth hormone can cause several side effects that are troubling. The most common are:

  • Generalized edema
  • Carpal tunnel syndrome
  • Muscle pain
  • Neuropathies (numbness and tingling)
  • The increase in the level of glucose in the blood, diabetes

You should carefully consider the risks and benefits of using the drug before deciding about potentially dangerous treatments.

The widespread abuse of HGH has led to regulations limiting its sale and distribution. Currently, HGH is recognized by the world anti-doping agency and the International Olympic Committee as a drug that improves efficiency. And it is prohibited for athletes from using it.

The website of provides information only for informational purposes. "IronSet" does not sell and does not call for use of potent substances, including anabolic steroids. This information is collected from public sources and can not serve as a basis for deciding on the use of certain drugs. The information presented on the website does not call for the use or distribution of potent substances.


Andrey is a coach, sports writer and editor. He is mainly involved in weightlifting. He also edits and writes articles for the IronSet blog where he shares his experiences. Andrey knows everything from warm-up to hard workout.

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